题目：Advanced Staging of Prostate and Breast Cancer by Raman Spectroscopic Imaging
报告人：Dr. Artem Pliss, Research Associate Professor, University at Buffalo, State University of New York
Abstract. Prostate cancer (PCa) and breast cancer (BrCa) are known for their frequent occurrence. However, standard prognostic factors are not sufficient for the unambiguous grading and reliable clinical prognosis, which drastically complicates the choice of clinical interventions and contributes to morbidity. To address needs of cancer management, we propose a development of Raman spectroscopic platform for quantitative analysis of common for these tumors biomarkers. Specifically, we propose to develop and apply two Raman techniques integrated in the same optical platform: (i) Coherent Anti-Stokes Raman Scattering (CARS) imaging, and (ii) Point measurement Raman spectroscopy coupled to Biomolecular Component Analysis algorithm. The synergic applications of CARS imaging and Raman microspectroscopy, discussed in this presentation, can lead to the development of bioassay for quantitative detection of biomarkers in PCa and BrCa lesions.
Dr. Artem Pliss currently holds a position as Research Associate Professor in the University at Buffalo, State University of New York. He obtained his B.S. and M.S. in Biology majoring in Cell Biology and Histology, Kiev State University, Kiev, Ukraine. He received his PhD in Cell Biology and Pathology from Charles University, Prague, Czech Republic. After postdoctoral training in the Department of Biological Sciences, SUNY at Buffalo, he joined the Institute for Lasers, Photonics and Biophotonics in the University at Buffalo. Dr. Pliss is specialized in bioimaging including conventional, confocal and multiphoton microscopy, fluorescence lifetime imaging, second harmonic microscopy, label-free vibrational spectroscopic imaging, and transmission electron microscopy. He has co-authored over 40 peer-reviewed articles including Nature Photonics, PNAS, JACS, Biomaterials and etc.