题目：Is Polyploidy the Origin of Resistance in Bacteria and Cancer?
报告人：Robert Hamilton Austin 教授（普林斯顿大学）
时间：2018年9月3日上午10:00—11:00
地点：南区光电楼1212会议室
报告内容: There is in a strong resemblance between the polyploidization response of cancer cells to chemotherapy resulting in increased fitness and the emergence of multi- nucleated bacterial when E. coli are treated with the geno- toxic antibiotic ciprofloxacin. Multi-chromosome-containing bacteria are able to divide asymmetrically at sub-lethal concentrations of ciprofloxacin and produce progeny with increased resistance. The mechanism of bacterial filament formation is analogous to the generation of polyploidal giant cancer cells, which suggests a unified fundamental role of polyploidy emergence in conferring resistance.
报告人简历：Bob Austin was a student of Hans Frauenfelder when biological physics in physics departments was an outlier. His interests have evolved from fundamentals of protein dynamics to quantum effects in biology to collective dynamics of agents in complex ecologies to the physics of cancer. Dr. Austin is a Fellow of the American Physical Society, Fellow of the Institute of Physics, member of the National Academy of Sciences, Member of the American Academy of Arts and Sciences. He won the Lilienfeld Prize and the Delbruck Prize of the American Physical Society. He served as the Chair of the Division of Biological Physics, was a Founder of the Topical Group on Medical Physics of the American Physical Society. He was the Chair of the NRC Review of the NIST Physics Lab.
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